Plant Transcription Factor Database
Previous version: v3.0
Arabidopsis thaliana
NF-YB Family
Species TF ID Description
AT1G09030.1nuclear factor Y, subunit B4
AT1G21970.1NF-YB family protein
AT2G13570.1nuclear factor Y, subunit B7
AT2G27470.1nuclear factor Y, subunit B11
AT2G37060.1nuclear factor Y, subunit B8
AT2G37060.2nuclear factor Y, subunit B8
AT2G37060.3nuclear factor Y, subunit B8
AT2G38880.1nuclear factor Y, subunit B1
AT2G38880.2nuclear factor Y, subunit B1
AT2G38880.3nuclear factor Y, subunit B1
AT2G38880.4nuclear factor Y, subunit B1
AT2G38880.5nuclear factor Y, subunit B1
AT2G38880.6nuclear factor Y, subunit B1
AT2G38880.7nuclear factor Y, subunit B1
AT2G38880.8nuclear factor Y, subunit B1
AT2G47810.1nuclear factor Y, subunit B5
AT3G53340.1nuclear factor Y, subunit B10
AT4G14540.1nuclear factor Y, subunit B3
AT5G08190.1nuclear factor Y, subunit B12
AT5G08190.2nuclear factor Y, subunit B12
AT5G23090.1nuclear factor Y, subunit B13
AT5G23090.2nuclear factor Y, subunit B13
AT5G23090.3nuclear factor Y, subunit B13
AT5G23090.4nuclear factor Y, subunit B13
AT5G47640.1nuclear factor Y, subunit B2
AT5G47670.1nuclear factor Y, subunit B6
AT5G47670.2nuclear factor Y, subunit B6
NF-YB Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982